Post-testicular sperm maturation, infertility and hypercholesterolaemia
نویسندگان
چکیده
منابع مشابه
Posttesticular sperm maturation, infertility, and hypercholesterolemia
Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol lev...
متن کاملEffect of Hypercholesterolaemia on Testicular Function and Sperm Physiology
The effect of hypercholesterolaemia on testicular endocrine and exocrine function was evaluated. Furthermore, the influence of hypercholesterolaemia on sperm quality, quantity, and fertilizing potential was appreciated. Eight mature rabbits (group A) were fed chow containing 3% cholesterol for 12 weeks. An additional six rabbits (group B) were fed normal chow for the same period. At the end of ...
متن کاملDietary Cholesterol-Induced Post-Testicular Infertility
This work shows that an overload of dietary cholesterol causes complete infertility in dyslipidemic male mice (the Liver X Receptor-deficient mouse model). Infertility resulted from post-testicular defects affecting the fertilizing potential of spermatozoa. Spermatozoa of cholesterol-fed lxr-/- animals were found to be dramatically less viable and motile, and highly susceptible to undergo a pre...
متن کاملPost-Meiotic Intra-Testicular Sperm Senescence in a Wild Vertebrate
There is growing interest in sperm senescence, both in its underlying mechanisms and evolutionary consequences, because it can impact the evolution of numerous life history traits. Previous studies have documented various types of sperm senescence, but evidence of post-meiotic intra-testicular sperm senescence in wild animals is lacking. To assess such senescence, we studied within-season chang...
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The fertilizing sperm's lengthiest unchartered voyage is through the longest, least-investigated organ in a man's body - the Epididymis. Over six meters long in men, ~80 meters in stallions and over one-hundred times a mouse's body length, there are few functions known aside from sperm storage and nutrition. While spermatogenesis is completed in the testes, here we demonstrate sperm centriole r...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2015
ISSN: 1008-682X
DOI: 10.4103/1008-682x.155536